Bookcover of Strategies to improve omeprazole solubility and permeability
Booktitle:

Strategies to improve omeprazole solubility and permeability

The use of cyclodextrins and mucoadhesive polymers in the buccal mucosa

LAP LAMBERT Academic Publishing (2011-11-29 )

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ISBN-13:

978-3-8443-3192-9

ISBN-10:
3844331921
EAN:
9783844331929
Book language:
English
Blurb/Shorttext:
The buccal mucosa is an alternative route for oral administration of drugs that show a strong first passage hepatic metabolism and high sensitivity to acidic environment in stomach, allowing improvement of its bioavailability. Nevertheless, administration of drugs in the buccal mucosa is limited due to its low permeability. Unlike that of the small intestine, the mucosa of the oral cavity has a stratified squamous epithelium with 20 to 40 layers of cells that act as a barrier against endogenous alterations and exogenous substances that reach the oral cavity. In addition, for an effective administration of drugs in the oral mucosa, it is necessary to increase the time of contact between the oral mucosa and the administered pharmaceutical form. From these characteristics, the objectives of this study are to increase the model drug (omeprazole) stability and solubility in the oral cavity environment (saliva), and simultaneously to use strategies to increase the drug absorption through the buccal mucosa.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Ana Figueiras, Francisco Veiga
Number of pages:
296
Published at:
2011-11-29
Stock:
Available
Category:
Pharmacy
Price:
79.00 €
Keywords:
Omeprazole, Cyclodextrins, Buccal Mucosa, Bioadhesive Polymers

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