Lipophilic drugs(Statins)and cardiovascular diseases in albino rats
lipophilic drugs (Statins) and cardiovascular diseases in male albino rats
978-3-659-13073-1
3659130737
252
2012-06-17
79.00 €
eng
https://images.our-assets.com/cover/230x230/9783659130731.jpg
https://images.our-assets.com/fullcover/230x230/9783659130731.jpg
https://images.our-assets.com/cover/2000x/9783659130731.jpg
https://images.our-assets.com/fullcover/2000x/9783659130731.jpg
In this study, the physiological and molecular effects of two cholesterol lowering agents , synthetic statin (atorvastatin) and natural statin (simvastatin) on diabetic and hypercholesterolemic adult male Wistar albino rats (Rattus norvegicus)at two doses, 10 and 40 mg/kg, for 8 weeks was investigated. Other physiological parameters were evaluated under this investigation, like: glucose, urea, uric acid, creatinine, total protein, albumin, globulin, A/G ratio, total, direct and indirect billirubin) To assess the beneficial effect of the drugs on liver genomic DNA, the (RE) analysis with 5 restriction endonucleases manifested variations in DNA digestion patterns in diabetic and hypercholesterolemic rats treated with atorvastatin and simavstatin. Such variation reflects and clarifies a restoration and repairing effect of statin on rat liver DNA in diabetic and hypercholesterolemic rats.
https://morebooks.de/books/gb/published_by/lap-lambert-academic-publishing/47/products
Zoology
https://morebooks.de/store/gb/book/lipophilic-drugsstatinsand-cardiovascular-diseases-in-albino-rats/isbn/978-3-659-13073-1