Bookcover of Formulation and Evalution of Mucoadhesive Nanosuspension for Ulcer
Booktitle:

Formulation and Evalution of Mucoadhesive Nanosuspension for Ulcer

Design and Development of mucoadhesive nanosuspension for peptic ulcer

LAP LAMBERT Academic Publishing (2012-06-04 )

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ISBN-13:

978-3-659-11824-1

ISBN-10:
3659118249
EAN:
9783659118241
Book language:
English
Blurb/Shorttext:
For most of the industry’s existence, pharmaceuticals have preliminary consisted of simple, fast-acting chemical compounds that are dispensed orally or as injectables. During the last three decades, however, formulations that control the rate and target specific area of the body for treatment have become increasingly common. Nowadays, nanosuspension technology with mucoadhesive principle comes into front for achieving to increased uptake and accumulation of drug in affected region of targeted organ. In the present study, preparation of nanosuspension for famotidine and curcumin by solvent evaporation technique as well as media milling technique using stabilizers was initially adopted. Formulation and process variables were identified based on particle size analysis and in vitro drug release. Optimized nanosuspension was characterized by particle size analysis, zeta potential determination, scanning electron microscopy (SEM). In vivo and ex-vivo study of optimized mucoadhesive nanosuspension was performed using rat stomach and compared with marketed suspension for healing of peptic ulcer.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Dhaval Patel, Patel Jayvadan K.
Number of pages:
160
Published at:
2012-06-04
Stock:
Available
Category:
Pharmacy
Price:
59.00 €
Keywords:
Factorial Design, Peptic Ulcer, Curcumin, Famotidine, Nanosuspension

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