Bookcover of Diagnostic methods of ANCA
Booktitle:

Diagnostic methods of ANCA

Different methods of detection of ANCA

LAP LAMBERT Academic Publishing (2012-05-06 )

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ISBN-13:

978-3-659-12005-3

ISBN-10:
3659120057
EAN:
9783659120053
Book language:
English
Blurb/Shorttext:
Autoimmune diseases occur when physiological tolerance to self-antigens is lost and thereafter, human body can not discriminate between self and non-self tissue. In autoimmunity, production of different auto-antibodies result in variety of pathologic manifestations. Auto-antibodies are hallmark of both systematic and organ specific autoimmune diseases. Among various autoantibodies, anti-neutrophil cytoplasmic antibody (ANCA) is a useful diagnostic tool for auto-immune glomerulonephritis. There are many techniques used for the detection of ANCA level. Here, we want to introduce some common techniques i.e. ELISA, IFT, cytogram and flow cytometer. Objectives: Current study was designed to determine sensitivity & specificity ANCA (p-ANCA and c-ANCA) of ELISA method. Results: ELISA is most sensitive method for c-ANCA and most specific method for p-ANCA. Diagnostic value of ELISA for both parameters c-ANCA & p-ANCA is same 95.31%. Conclusion: ELISA is sensitive as well as specific method for the detection of ANCA. Besides that indirect immunoflorecent technique (IIF) remains the gold standard method for the detection of ANCA (c-ANCA & p-ANCA).
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Maria Arif, Taha Arif
Number of pages:
68
Published at:
2012-05-06
Stock:
Available
Category:
Other
Price:
49.00 €
Keywords:
Glomerulonephritis, ANCA, Autoimmune diseases.

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