Bookcover of Azole Derivatives as an Protein Tyrosin Kinase Inhibitors
Booktitle:

Azole Derivatives as an Protein Tyrosin Kinase Inhibitors

Synthesis and Antiproliferative Evaluation of Imatinib analogs

LAP LAMBERT Academic Publishing (2012-10-23 )

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ISBN-13:

978-3-659-28294-2

ISBN-10:
3659282944
EAN:
9783659282942
Book language:
English
Blurb/Shorttext:
In the present book “The Azoles Derivatives as Potent Protein Tyrosine Kinase Inhibitor”, we provide an exhaustive literature regarding the Antiproliferative potential of Protein Tyrosine Kinase Inhibitors. Various analogous of imatinib were Designed and prepared by replacing the pyrimidine ring of imatinib with an azole nucleous like Imidazole, Benzimidazole and Benzthiazole. Imatinib an well reputed anti-cancer agent contain pyrimidine ring, composition of various biological enzymes and proteins of normal cell, as analogous of ATP inhibit the natural cell protein Kinase, hence responsible for non-specificity in activity with low selectivity and side effects. BMS-33197 an excellent Bcr-Abl kinase inhibitor contain an oxazole nucleolus responsible for its activity so various imatinib analogous were prepared isosterically.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Yogesh Agrawal, Mona Agrawal
Number of pages:
84
Published at:
2012-10-23
Stock:
Available
Category:
Other
Price:
49.00 €
Keywords:
Synthesis, design, Imatinib, Antiproliferative, Protein Tyrosine Kinase Inhibitors

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