Bookcover of Anxiolytic Effect Of 6-Shogaol In Mice
Booktitle:

Anxiolytic Effect Of 6-Shogaol In Mice

LAP LAMBERT Academic Publishing (2013-09-29 )

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ISBN-13:

978-3-659-44959-8

ISBN-10:
3659449598
EAN:
9783659449598
Book language:
English
Blurb/Shorttext:
The purpose of this study was to demonstrate the anxiolytic-like effects of 6-Shogaol obtained from Ginger root(Zingiber officinale Roscoe, Zingiberacaceae) in mice using various behavioral paradigms.Goups of mice treated with doses of 6-Shogaol 20 mg/kg (i.p.) and 30 mg/kg(i.p.) and diazepam 1 mg/kg( i.p.) did not show any significant effects on locomotion. The same treatment increased in the percentage of time and entries into open arms of the elevated plus maze (EPM). 6-Shogaol at the doses of 20 and 30 mg/kg and DZ (1 mg/kg) induced a significant increase in the time spent in the light box without affecting other parameters. Same treatment induced a significant increase in the head dip counts and head dip duration which was similar to standard dose without affecting locomotion (no. of squares crossed). The aim of the current study was to screen the anxiolytic effect of 6- Shogaol in experimental models of anxiety in mice. The major active ingredients of ginger (6-Shogaol) contribute to their multiple medicinal properties. The present study demonstrated for the first time that 6- Shogaol has an anxiolytic effect.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Neelam Yadav
Number of pages:
108
Published at:
2013-09-29
Stock:
Available
Category:
Pharmacy
Price:
362.89 R$
Keywords:
Anxiety, EPM, Locomotor Activity, Pathophysiology of Anxiety, 6- Shogaol, Light and Dark Model, Hole Board, mice

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