3-deoxyglucosone
978-613-3-82388-4
6133823887
108
2010-12-07
1,380.99 NT$
eng
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. 3 deoxyglucosone (3DG) is a dicarbonyl sugar that is synthesized through the Maillard reaction, and is detoxified to 3-deoxyfructose and 2-keto-3-deoxygluconic acid. 3DG is a precursor for the formation of advanced glycation endproducts (AGEs): 3DG rapidly reacts with protein amino groups to form AGEs such as imidazolone, pyrraline, N6-(carboxymethyl)lysine and pentosidine. 3DG as well as AGEs play a role in the modification and cross-linking of long-lived proteins such as crystallin and collagen, contributing to diseases such as the vascular complications of diabetes, atherosclerosis, hypertension, Alzheimer’s disease inflammation and aging.
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