PRMT4 Pathway kitap kapağı
Kitap başlığı:

PRMT4 Pathway

Betascript Publishing (2010-07-03 )

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ISBN-13:

978-613-0-58778-9

ISBN-10:
6130587783
EAN:
9786130587789
Kitabın dili:
İngilizce
Özet:
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Protein arginine N-methyltransferase-4 methylation of arginine residues within proteins plays a critical key role in transcriptional regulation (see the PRMT4 pathway on the left). PRMT4 binds to the classes of transcriptional activators known as p160 and CBP/p300. The modified forms of these proteins are involved in stimulation of gene expression via steroid hormone receptors. Significantly, PRMT4 methylates core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. PRMT4 recruitment chromatin by binding to coactivators increases histone methylation and enhances the accessibility of promoter regions for transcription. Methylation of the transcriptional coactivator CBP by PRMT4 inhibits binding to CREB and thereby partitions the limited cellular pool of CBP for steroid hormone receptor interaction.
Yayınevi:
Betascript Publishing
Websitesi:
https://www.betascript-publishing.com/
Düzenleyen:
Lambert M. Surhone, Miriam T. Timpledon, Susan F. Marseken
Sayfa sayısı:
144
Yayın tarihi:
2010-07-03
Hisse:
Mevcut
Kategori:
Tıp
Fiyat:
45.00 €
Anahtar kelimeler:
Arginine, Methyltransferase, Methylation, Transcriptional, Proteins, gene expression, Hormone Receptor, Chromatin, Promoter

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