Discovery of HIV-1 Integrase Inhibitors kitap kapağı
Kitap başlığı:

Discovery of HIV-1 Integrase Inhibitors

Furan and Sulfonamide-based Integrase Inhibitors

VDM Verlag Dr. Müller (2010-11-18 )

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ISBN-13:

978-3-639-30281-3

ISBN-10:
3639302818
EAN:
9783639302813
Kitabın dili:
İngilizce
Özet:
Highly active antiretroviral therapy (HAART) is the current treatment regimen for HIV/AIDS, a disease that has claimed millions worldwide. HAART is a cocktail that inhibits different stages of the viral life cycle targeting protease, reverse transcriptase, and often includes anti-fusion inhibitor enfurvitide. The addition of HIV-1 integrase (IN) inhibitor raltegravir to HAART reveals a decrease of the virus to near undetectable levels in treatment-experienced patients. Although these successes are encouraging for antiviral therapy, specific mutations resistant to raltegravir have also appeared. Drug resistant mutations is the inevitable signature of HIV with a merry-go-round history of antiviral drug development and viral evolution, highlighting the need to identify new leads for IN inhibition. Absent of a cellular
Yayınevi:
VDM Verlag Dr. Müller
Websitesi:
http://www.vdm-verlag.de
Yazar:
Tino Sanchez
Sayfa sayısı:
60
Yayın tarihi:
2010-11-18
Hisse:
Mevcut
Kategori:
Eczacılık
Fiyat:
49.00 €
Anahtar kelimeler:
aids, HIV, inhibitors, Integrase, Drugs, Virus, Recombinant, pharmacology, Furan, dithiazines

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