Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene.This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element-binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition.