Acute myeloblastic leukemia with maturation
Acute myeloid leukemia, Chromosome 8 (human), Chromosome 21 (human), RUNX1
978-613-9-77027-4
6139770270
136
2012-01-02
45.00 €
eng
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. M2 is a subtype of AML (Acute Myeloid Leukemia). It is also known as "Acute Myeloblastic Leukemia with Maturation". This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21). On both sides of the splice the DNA coded for different proteins, RUNX1 and ETO, These two sequences are then transcribed and translated into a single large protein, "M2 AML" which allows the cell to divide unchecked, leading to cancer.
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