Capa do livro de Role of TCF in body axis formation
Título do livro:

Role of TCF in body axis formation

Discovery of a Dual Action of XTCF-3 in Xenopus Body Axis Formation

LAP LAMBERT Academic Publishing (2009-10-13 )

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ISBN- 1 3:

978-3-8383-2052-6

ISBN- 1 0:
3838320522
EAN:
9783838320526
Idioma do livro:
Inglês
Anotações e citações/ texto breve:
A novel role of TCF family in body axis formation. Revolutionary high impact discoveries are described, elucidating the missing link in the Wnt pathway and protein-TCF combinations with dual functions. By studying the primary axis formation of Xenopus laevis, it was firstly shown that, in combination with beta-catenin, TCF acts as a potent activator of proto-oncogenes. Secondly, it was discovered that in combination with the Groucho family of proteins, TCF acts as suppressor of oncogene transcription. Stronlgy suggesting that TCF controls oncogene transcription in a dual fashion. These discoveries contributed to the origination of a major area of cancer research and opened multiple angles for cancer therapy development.
Editora:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
Por (autor):
Miranda Molenaar
Número de páginas:
80
Publicado em:
2009-10-13
Stock:
Disponível
Categoria:
Biologia
Preço:
49.00 €
Palavras chave:
T-Cell Factor, TCF, LEF, XTCF-3, beta-Catenin, β-Cat, Wnt, Groucho, GRG, XGrg-4, XGrg-5, Xenopus laevis, WNT signaling pathway, proto-oncogene, embryonic development, body axis formation, ventral, dorsal, cancer therapy

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