Capa do livro de Pyrazoles and Pyrrolo[3,2-c]pyridines as Anticancer Agents
Título do livro:

Pyrazoles and Pyrrolo[3,2-c]pyridines as Anticancer Agents

Novel Pyrazoles and Pyrrolo[3,2-c]pyridines as Potential Anticancer Agents

LAP LAMBERT Academic Publishing (2012-08-31 )

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ISBN- 1 3:

978-3-659-23161-2

ISBN- 1 0:
3659231614
EAN:
9783659231612
Idioma do livro:
Inglês
Anotações e citações/ texto breve:
In the present investigation, novel pyrazoles and pyrrolo[3,2-c]pyridines have been designed as potential antiproliferative agents against different types of cancer. Their antiproliferative activities were examined against 61 cancer cell lines of 9 different cancer types. Biological investigation of representative target compounds at molecular level was conducted in order to investigate the possible mechanism(s) of antiproliferative activity of our target compounds. In addition, molecular modeling study was carried out. Some compounds showed broad-spectrum antiproliferative activity, while others demonstrated selectivity over certain types of cancer. Our research led to discovery a selective FMS kinase inhibitor, multiple-kinase inhibitor, ERK kinase inhibitors, and dual ERK/COX-2 inhibitors. This work led to development of novel lead anticancer agents, which can be utilized for future development of potential anticancer agents.
Editora:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
Por (autor):
Mohammed I. El-Gamal, Chang-Hyun Oh
Número de páginas:
320
Publicado em:
2012-08-31
Stock:
Disponível
Categoria:
Química
Preço:
79 €
Palavras chave:
1, anticancer, Medicinal Chemistry, 3, pyrazole, Kinase inhibitors, Pharmaceutical Chemistry, 2-c]pyridine, Dual kinase/COX-2 inhibitors, Antiproliferative, Pyrrolo[3, COX-2 inhibitors, 4-Triarylpyrazole, 4-Diarylpyrazole-1-carboxamide, Diarylurea, Diarylamide, Bisamide

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