Capa do livro de Novel iron chelators for iron overload disease and cancer treatment
Título do livro:

Novel iron chelators for iron overload disease and cancer treatment

Development of novel iron chelators for the treatment of iron overload disease and cancer

LAP LAMBERT Academic Publishing (2010-05-14 )

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ISBN- 1 3:

978-3-8383-0028-3

ISBN- 1 0:
3838300289
EAN:
9783838300283
Idioma do livro:
Inglês
Anotações e citações/ texto breve:
Iron (Fe) chelation therapy involves the use of drugs that avidly bind Fe from biological systems. Iron chelators were developed for the treatment of Fe overload diseases, B-thalassemia and Friedreich's ataxia. However, the increased requirement for Fe in rapidly proliferating cancer cells, compared to normal cells, makes Fe a target for cancer chemotherapy. Iron chelators remove Fe from Fe-containing proteins, including ribonucleotide reductase, a key enzyme involved in the rate-limiting step of DNA synthesis and inhibit proliferation. Chelators with potent antiproliferative activity also demonstrate the ability to form Fe complexes that redox cycle. This leads to the generation of reactive oxygen species which induce DNA oxidation and mitochondrial damage. The investigations described in this book detail several structural features involved in targeting ligands for either the treatment of Fe overload disease or cancer chemotherapy. These findings emphasise the importance of donor atom identity and inductive effects on the redox cycling and antiproliferative activity of aroylhydrazone, thiohydrazone and thiosemicarbazone Fe chelators.
Editora:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
Por (autor):
Danuta Kalinowski, Des R. Richardson
Número de páginas:
288
Publicado em:
2010-05-14
Stock:
Disponível
Categoria:
Farmácia
Preço:
79 €
Palavras chave:
iron, Chelators, cancer, structure-activity relationships, Chemotherapeutics, complex, Iron Overload Disease, chemistry, biology, Iron, Cancer, Structure-Activity Relationships, Complex, Chemistry, Biology

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