Indoleamine 2,3-dioxygenase
978-613-3-05730-2
6133057300
76
2010-10-18
34.00 €
eng
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). In humans, IDO is encoded by the INDO gene. Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine.
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