Capa do livro de CONTROLLED RELEASE NIFEDIPINE MICROPARTICLES FROM STARCH ACETATE
Título do livro:

CONTROLLED RELEASE NIFEDIPINE MICROPARTICLES FROM STARCH ACETATE

DESIGN AND EVALUATION OF A CONTROLLED RELEASE MICROPARTICLES FROM STARCH ACETATE

LAP LAMBERT Academic Publishing (2010-11-03 )

Books loader

Omni badge Apto para vale
ISBN- 1 3:

978-3-8433-6824-7

ISBN- 1 0:
3843368244
EAN:
9783843368247
Idioma do livro:
Inglês
Anotações e citações/ texto breve:
The present investigation involves development of a CR Nifedipine microparticulate system utilizing starch acetate as the rate controlling polymer. SA was manufactured in house form native starches and characterization for degree of substitution (dS) and acetyl content among other parameters. An emulsification solvent evaporation technique was followed to develop microparticles of varying drug- polymer ratio''s with triethyl citrate plasticizers at different levels. The prepared microparticles were subjected to standard evaluation such as yield, particle size, surface topography, drug content and in vitro dissolution studies.The development formulations were subsequently optimized through a simplex lattice mixture design to predict the optimum formulations matching the target official release profiles. It was found that two blend of development formulations, namely F1: F5 (0.822:0.1780) and F5: F13 (0.041:0.959) could closely resemble official specification and hence were optimum. The developed multiparticulate systems of Nifedipine are expected to provide a better clinical option for treatment of persistent/chronic angina and hypertension.
Editora:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
Por (autor):
Swarupananda Mukherjee
Número de páginas:
112
Publicado em:
2010-11-03
Stock:
Disponível
Categoria:
Tecnología química
Preço:
49 €
Palavras chave:
microparticles, Simplex, Controlled, SEM

Books loader

Boletim informativo

Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay PayPal CryptoWallet Transferência Bancária

  0 produtos no carrinho
Editar carrinho
Loading frontend
LOADING