Capa do livro de Azole Derivatives as an Protein Tyrosin Kinase Inhibitors
Título do livro:

Azole Derivatives as an Protein Tyrosin Kinase Inhibitors

Synthesis and Antiproliferative Evaluation of Imatinib analogs

LAP LAMBERT Academic Publishing (2012-10-23 )

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ISBN- 1 3:

978-3-659-28294-2

ISBN- 1 0:
3659282944
EAN:
9783659282942
Idioma do livro:
Inglês
Anotações e citações/ texto breve:
In the present book “The Azoles Derivatives as Potent Protein Tyrosine Kinase Inhibitor”, we provide an exhaustive literature regarding the Antiproliferative potential of Protein Tyrosine Kinase Inhibitors. Various analogous of imatinib were Designed and prepared by replacing the pyrimidine ring of imatinib with an azole nucleous like Imidazole, Benzimidazole and Benzthiazole. Imatinib an well reputed anti-cancer agent contain pyrimidine ring, composition of various biological enzymes and proteins of normal cell, as analogous of ATP inhibit the natural cell protein Kinase, hence responsible for non-specificity in activity with low selectivity and side effects. BMS-33197 an excellent Bcr-Abl kinase inhibitor contain an oxazole nucleolus responsible for its activity so various imatinib analogous were prepared isosterically.
Editora:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
Por (autor):
Yogesh Agrawal, Mona Agrawal
Número de páginas:
84
Publicado em:
2012-10-23
Stock:
Disponível
Categoria:
Outros
Preço:
49 €
Palavras chave:
Synthesis, design, Imatinib, Antiproliferative, Protein Tyrosine Kinase Inhibitors

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