Borítókép a YM-348 - hoz
Könyv címe:

YM-348

Betascript Publishing (10.07.2010 )

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ISBN-13:

978-613-0-97155-7

ISBN-10:
6130971559
EAN:
9786130971557
Könyv nyelve:
angol
Ismertető:
Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. YM-348 is an indazole derivative drug which acts as a potent and selective 5-HT2C receptor agonist, with an EC50 of 1nM and 15x selectivity over 5-HT2A, although it only has moderate selectivity of 3x over the closely related 5-HT2B receptor. It has thermogenic and anorectic effects in animal studies, making it potentially useful for the treatment of obesity.AL-34662 is an indazole derivative drug that is being developed for the treatment of glaucoma. It acts as a selective 5-HT2A receptor agonist, the same target as that of hallucinogenic drugs like psilocin, but unlike these drugs, AL-34662 was designed specifically as a peripherally selective drug, which does not cross the blood-brain barrier. This means that AL-34662 can exploit a useful side effect of the hallucinogenic 5-HT2A agonists, namely reduction in intra-ocular pressure and hence relief from the symptoms of glaucoma, but without causing the hallucinogenic effects that make centrally active 5-HT2A agonists unsuitable for clinical use.
Kiadó:
Betascript Publishing
Weboldal:
https://www.betascript-publishing.com/
Szerkesztette:
Lambert M. Surhone, Miriam T. Timpledon, Susan F. Marseken
Oldalszám:
116
Kiadja:
10.07.2010
Raktárkészlet:
Raktáron
Kategória:
Gyógyszerészet
Ár:
39,00 €
Kulcsszavak:
AL- 34662, AL- 38022A, Ro60- 0175, glaucoma, Indazole, Serotonin

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