Borítókép a The Study of Hypertension:Antagonism of alpha 1D receptor - hoz
Könyv címe:

The Study of Hypertension:Antagonism of alpha 1D receptor

Complete work on Design, Synthesis and Biological evaluation of novel Anti-hypertensive agents

LAP LAMBERT Academic Publishing (29.09.2013 )

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ISBN-13:

978-3-659-46167-5

ISBN-10:
3659461679
EAN:
9783659461675
Könyv nyelve:
angol
Ismertető:
The development of new therapies to treat hypertension effectively is currently an intensive area of research. To achieve this objective quantitative structure activity relationship (QSAR) study was carried out on a reported series of phthalazine derivatives as alpha-1d antagonist, as it provides the rationale for the changes in the pharmacophore to have more potent and less toxic analogue. In this article, we report 2D and 3D QSAR studies for the set of 20, alpha-1d antagonist. A simple and convenient procedure has been developed for the synthesis of Novel 1 phthalazinone and 1, 4phthalazinedione derivatives using Schotten–Baumann reaction and Gabriel Michael reaction respectively. All compounds have been characterized by IR, NMR,and MASS spectroscopy.
Kiadó:
LAP LAMBERT Academic Publishing
Weboldal:
https://www.lap-publishing.com/
Szerezte:
Vijay Rakholiya, Rohan Bamane, Santosh Gandhi
Oldalszám:
264
Kiadja:
29.09.2013
Raktárkészlet:
Raktáron
Kategória:
Gyógyszerészet
Ár:
82,90 €
Kulcsszavak:
Molecular Modeling, Phathalazine derivatives, Synthesis & Biological evaluation of Phathalazine derivatives

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