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Könyv címe:

Synthesis and biological testing of 1-adamantyl derivatives

Different synthetic methods and biological evaluation of adamantane containing derivatives

VDM Verlag Dr. Müller (01.04.2010 )

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ISBN-13:

978-3-639-24670-4

ISBN-10:
3639246705
EAN:
9783639246704
Könyv nyelve:
angol
Ismertető:
Several adamantane derivatives have long been known for diverse biological properties, mainly as antiviral, antibacterial, antifungal and anti-inflammatory agents. adamantyl derivatives were recently reported to possess 11-HSD1 inhibitory activities. In addition, 1,2,4-triazole and 1,3,4-thiadiazole were reported to constitute the pharmacologically active moiety of several compounds. On these bases new series of 1-adamantyl derivatives, in which the adamantyl moiety was attached to 1,2,4-triazole, 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole or 1,3,4-thiadiazole nucleus, have been synthesized as potential bioactive agents All the synthesized compounds were tested for their in vitro growth inhibitory activity against a panel of standard strains of pathogenic microorganism including Gram-positive bacteria, Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. In addition, the acute anti-inflammatory activity of a representative compounds was determined in vivo following the carrageenan-induced paw oedema method in rats.
Kiadó:
VDM Verlag Dr. Müller
Weboldal:
http://www.vdm-verlag.de
Szerezte:
Ebtehal AlAbdullah, Dr. Ali, Dr. Ihsan
Oldalszám:
176
Kiadja:
01.04.2010
Raktárkészlet:
Raktáron
Kategória:
Gyógyszerészet
Ár:
68,00 €
Kulcsszavak:
((Adamantyl-1, 2, 4-triazole)), 4-triazolo[3, 4-b][1, 3, 4] thiadiazole)), 4-thiadiazole)), microwave synthesis, Antiviral, antibacterial, antiinflamatory, 11-HSD1 inhibitory activities, antifungal, 4] thiadiazole))

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