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In Search of Selective 11β-HSD 1 Inhibitors without Nephrotoxicity

An Approach to Resolve the Metabolic Syndrome by Virtual Based Screening

LAP LAMBERT Academic Publishing (20.10.2015 )

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ISBN-13:

978-3-659-79001-0

ISBN-10:
365979001X
EAN:
9783659790010
Könyv nyelve:
angol
Ismertető:
Over expression of 11β-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11β-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11β-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11β-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski’s rule and ADME prediction implemented to find out the potent and selective 11 β-HSD 1 analog of corosolic acid without nephrotoxicity.
Kiadó:
LAP LAMBERT Academic Publishing
Weboldal:
https://www.lap-publishing.com/
Szerezte:
Rakesh Jagtap, Harun Patel, Kiran Dhangar
Oldalszám:
56
Kiadja:
20.10.2015
Raktárkészlet:
Raktáron
Kategória:
Gyógyszerészet
Ár:
39,90 €
Kulcsszavak:
ADME, Virtual screening, 11β-HSD 1, PASS toxicity, Lipnski’s Rule

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