Borítókép a Human Leukocyte Antigen-G and Cardiac Allograft Vasculopathy - hoz
Könyv címe:

Human Leukocyte Antigen-G and Cardiac Allograft Vasculopathy

LAP LAMBERT Academic Publishing (11.11.2014 )

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ISBN-13:

978-3-659-59294-2

ISBN-10:
3659592943
EAN:
9783659592942
Könyv nyelve:
angol
Ismertető:
Human leukocyte antigen-G (HLA-G), a non-classical MHC I protein, plays an essential role in immune tolerance and is associated with a lower incidence of graft rejection and cardiac allograft vasculopathy (CAV). To examine the pattern of HLA-G expression post-transplantation we determined that HLA-G can be up-regulated in smooth muscle cells (SMCs) following exposure to everolimus. We also determined that HLA-G at 500 and 1000 ng/ml reduces SMC proliferation. In further studies, treatment with HLA-G inhibited TNFα-stimulated neutrophil adhesion to endothelial cells (ECs) at all concentrations tested (0.1-1 ng/ml), suggesting a role in inflammation. The expression of HLA-G is influenced by a polymorphism in the HLA-G gene. We sought to determine if the 14bp insertion/deletion polymorphism can predict the development of CAV. There was no association between this polymorphism and CAV; however, this study had a small number of patients; therefore further investigations are needed to confirm these findings.
Kiadó:
LAP LAMBERT Academic Publishing
Weboldal:
https://www.lap-publishing.com/
Szerezte:
Amelia G. Mociornita
Oldalszám:
176
Kiadja:
11.11.2014
Raktárkészlet:
Raktáron
Kategória:
Gyógyszerészet
Ár:
71,90 €
Kulcsszavak:
heart transplantation, cardiac allograft vasculopathy, HLA-G

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