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Estrogen's role in cardiovascular health

The role of estrogen in the maintenance of healthy endothelium under conditions of oxidative stress, apoptosis and angiogenesis

VDM Verlag Dr. Müller (21.05.2009 )

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ISBN-13:

978-3-639-15299-9

ISBN-10:
3639152999
EAN:
9783639152999
Könyv nyelve:
angol
Ismertető:
The place of estrogen in women's health remains controversial. Premenopausal women have a lower prevalence of cardiovascular disease (CVD) than men and hormone replacement therapy (HRT) decreases CVD in postmenopausal women. However, clinical trials failed to substantiate a protective effect of HRT and even showed some harm. Estrogen rapidly mediates the activation of endothelial nitric oxide synthase (eNOS) and increases production of nitric oxide (NO), an important factor for endothelial health. Distinctive results for eNOS, NO and superoxide levels are highlighted by studies on acute and long term effects of estrogen. In human endothelial cells, apoptosis induced by oxidized low-density lipoprotein and the cytokine TNFα, associated with atherosclerosis, is reduced by estrogen. Estrogen's angiogenic properties help healthy endothelium respond to injury, but they also potentiate TNFα- induced angiogenesis, which revascularizes plaques of women with advanced atherosclerosis and exacerbates cardiovascular events. Researchers and clinicians could appreciate this contribution to the undestanding of the paradoxical effects of estrogen on the vascular wall.
Kiadó:
VDM Verlag Dr. Müller
Weboldal:
http://www.vdm-verlag.de
Szerezte:
Maria Florian
Oldalszám:
252
Kiadja:
21.05.2009
Raktárkészlet:
Raktáron
Kategória:
Bilógia
Ár:
79,00 €
Kulcsszavak:
Estrogen, postmenopausal, hormone replacement, oxidative stress, endothelial cell, nitric oxide, Atherosclerosis, oxidized low-density lipoprotein, TNF-alpha, angiogenesis

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