Bookcover of The Study of Hypertension:Antagonism of alpha 1D receptor
Booktitle:

The Study of Hypertension:Antagonism of alpha 1D receptor

Complete work on Design, Synthesis and Biological evaluation of novel Anti-hypertensive agents

LAP LAMBERT Academic Publishing (2013-09-29 )

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ISBN-13:

978-3-659-46167-5

ISBN-10:
3659461679
EAN:
9783659461675
Book language:
English
Blurb/Shorttext:
The development of new therapies to treat hypertension effectively is currently an intensive area of research. To achieve this objective quantitative structure activity relationship (QSAR) study was carried out on a reported series of phthalazine derivatives as alpha-1d antagonist, as it provides the rationale for the changes in the pharmacophore to have more potent and less toxic analogue. In this article, we report 2D and 3D QSAR studies for the set of 20, alpha-1d antagonist. A simple and convenient procedure has been developed for the synthesis of Novel 1 phthalazinone and 1, 4phthalazinedione derivatives using Schotten–Baumann reaction and Gabriel Michael reaction respectively. All compounds have been characterized by IR, NMR,and MASS spectroscopy.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Vijay Rakholiya, Rohan Bamane, Santosh Gandhi
Number of pages:
264
Published on:
2013-09-29
Stock:
Available
Category:
Pharmacy
Price:
82.90 €
Keywords:
Molecular Modeling, Phathalazine derivatives, Synthesis & Biological evaluation of Phathalazine derivatives

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