Bookcover of Simultaneous estimation of antiulcer and antemetic drug by using HPLC
Booktitle:

Simultaneous estimation of antiulcer and antemetic drug by using HPLC

Determination of Domperidone and Esomaprazole Magnesium in Tablet Dosage Form by RP-HPLC

LAP LAMBERT Academic Publishing (2012-03-01 )

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ISBN-13:

978-3-8484-0839-9

ISBN-10:
3848408392
EAN:
9783848408399
Book language:
English
Blurb/Shorttext:
A simple, sensitive and validated HPLC method has been developed to determine esomeprazole and domperidone in tablet dosage form. The chromatographic separation was achieved on a hyperchrome C-18 column column (4.6 x 150mm, 5μ particle size) analytical column using a mixture of acetonitrile: Phosphate buffer (pH 5.0) in the ratio of 60:40 (v/v) used as the mobile phase, at a flow rate of 1.0 ml/min and detector wavelength at 290 nm. The validation of the proposed method was carried out for specificity, linearity, accuracy, precision, limit of detection, limit of quantitation and robustness. Linearity of method was found to be in concentration range 10-50 μg/ml for esomeprazole and 5-25 μg/ml for domperidone with correlation coefficient greater than 0.9999. The retention time of domperidone and esomeprazole was found to be 2.92 and 3.91 min respectively. The method can be used for simultaneous determination of esomeprazole and domperidone.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Vinod Sahu, Nilesh Jain, Surendra Jain
Number of pages:
84
Published on:
2012-03-01
Stock:
Available
Category:
Pharmacy
Price:
59.00 €
Keywords:
Analytical chemistry

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