Bookcover of Polyalthia longifolia: A Potential Antimalaria and Antipyretic Remedy
Booktitle:

Polyalthia longifolia: A Potential Antimalaria and Antipyretic Remedy

Investigating the antiplasmodial and antipyretic activities of Polyalthia longifolia var pendula (Annonaceae)

LAP LAMBERT Academic Publishing (2020-03-22 )

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ISBN-13:

978-620-0-78635-7

ISBN-10:
6200786356
EAN:
9786200786357
Book language:
English
Blurb/Shorttext:
Polyalthia longifolia var. pendula is used as a folkloric remedy for the treatment of malaria and fever in tropical and subtropical regions of the world. The objective of this study is to investigate the antiplasmodial and antipyretic activities of Polyalthia longifolia var. pendula and thus justify its use as an effective remedy for malaria and fever. It also describes the isolation and characterization of active constituents from the plant. The crude methanol extracts of the leaves, stem bark and roots of the plant were assessed for antiplasmodial and antipyretic activities. The antiplasmodial activities of the extracts and isolated compounds were performed using the WHO Mark III Microtest assay. The extracts were tested in vitro against the chloroquine sensitive 3D7 strain of the Plasmodium falciparum parasite in continuous culture. The extracts were prepared at concentrations ranging between 0.097 μg/ml and 100 μg/ml. All three extracts were active against P. falciparum, with the stem bark extract being the most active (IC50 =4.89 μg/ml). Artesunate was used as the reference drug (IC50 =0.59 μg/ml).
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Cindy Kitcher
Number of pages:
236
Published on:
2020-03-22
Stock:
Available
Category:
Botany
Price:
76.90 €
Keywords:
POLYALTHIA LONGIFOLIA, ANTIMALARIA AND ANTIPYRETIC REMEDY, Polyalthia longifolia var pendula (Annonaceae), botany

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