Bookcover of O-linked N-Acetylglucosaminylation of Sp1 Inhibits the HIV-1 Promoter
Booktitle:

O-linked N-Acetylglucosaminylation of Sp1 Inhibits the HIV-1 Promoter

Sweet Perspectives to Repress the Human Immunodeficiency Virus Type-1

Südwestdeutscher Verlag für Hochschulschriften (2009-10-12 )

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ISBN-13:

978-3-8381-1144-5

ISBN-10:
3838111443
EAN:
9783838111445
Book language:
English
Blurb/Shorttext:
The AIDS pandemic is caused by the Human Immunodeficiency Virus Type-1 (HIV-1). To date, there is neither a vaccine against HIV-1, nor a cure for AIDS available. HIV-1 gene expression and replication is regulated by the binding of cellular transcription factors to specific regulatory sites in the 5’-long terminal repeat (LTR) promoter. In this study it is demonstrated that the cell’s glucose metabolism represses the replication of HIV- 1. This is based on the enzyme O-GlcNAc transferase (OGT), which is activated by increased glucose concentration and modifies proteins posttranslationally with the monosaccharide O- GlcNAc. OGT blocks the cellular transcription factor Sp1, which is essential for the replication of HIV-1 and thereby represses virus propagation. Hence, the establishment of a metabolic treatment might supplement the repertoire of antiretroviral therapies against AIDS.
Publishing house:
Südwestdeutscher Verlag für Hochschulschriften
Website:
https://www.svh-verlag.de
By (author) :
Ramona Jochmann
Number of pages:
120
Published on:
2009-10-12
Stock:
Available
Category:
Biology
Price:
53.90 €
Keywords:
virology, Cell Biology, HIV-1, O-GlcNAcylation, glucose metabolism, Sp1, Posttranslational Modification, Virology, Cell biology, posttranslational modification

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