Bookcover of INSIDE THE PLASMA AMINE OXIDASE
Booktitle:

INSIDE THE PLASMA AMINE OXIDASE

PRELIMINARY DRUG DISCOVERY STUDY OF PLASMA AMINE OXIDASE: STRUCTURAL BASIS OF SUBSTRATE AND INHIBITORY ACTIVITY OF BOVINE PLASMA AMINE OXIDASE

VDM Verlag Dr. Müller (2010-05-04 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-639-25568-3

ISBN-10:
3639255682
EAN:
9783639255683
Book language:
English
Blurb/Shorttext:
The copper-containing amine oxidases, like bovine plasma amine oxidase (BPAO), carry out a transaminative oxidation of primary amines to aldehydes via use of an active site Tyr-derived 2,4,5-trihydroxyphenylalanine quinone (TPQ) cofactor. Propargylamine is a potent inactivator of BPAO (IC50 = 3 µM), possibly through active-site modification by the a,ß-unsaturated aldehyde turnover product, but the simple structure is expected to confer low selectivity. On the basis of the finding by previous students that certain extended conjugation analogs such as 1,6-diamino-2,4- hexadiyne and 3-cyanopropargylamine preserve strong inactivation potency, other extended conjugation analogs of propargylamine were evaluated. In particular, 1-amino-2,4-hexadiynes with a 6-OH rather than 6-NH2 group were found to be potent inhibitors.
Publishing house:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
By (author) :
Yanwen Chen
Number of pages:
216
Published on:
2010-05-04
Stock:
Available
Category:
Organic chemistry
Price:
79.00 €
Keywords:
Enzyme, Bio-organic chemistry, structure, Amine oxidase, inhibitor, Substrate

Books loader

Newsletter

Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Paypal CryptoWallet Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING