Bookcover of Imaging of creatine deposits in human CNS tissues
Booktitle:

Imaging of creatine deposits in human CNS tissues

with FTIR and XRF microspectroscopy

LAP LAMBERT Academic Publishing (2010-08-10 )

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ISBN-13:

978-3-8383-8483-2

ISBN-10:
3838384830
EAN:
9783838384832
Book language:
English
Blurb/Shorttext:
Synchrotron infrared spectromicroscopy and X-Ray Fluorescence spectromicroscopy have been applied to imagine human central nervous system tissue. Untreated, flash frozen tissue samples were analyzed at micron level spatial resolution to obtain information about chemical composition of the sample. Bright synchrotron light allowed the high spatial resolution (8-10 microns) needed for this study. In the family of neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS) is the most frequent cause of adult onset. ALS symptoms include: generalized weakness and muscle atrophy. The motor cortex, brain stem, spinal cord and substantia nigra were mapped using infrared spectromicroscopy and the results were analysed for protein, lipids and creatine levels. Creatine is a small molecule which plays important role in metabolism. Creatine was found to be focally elevated and formed deposits located in the human ALS CNS tissue. Focally elevated creatine may be a marker of the disease process, indicative of disturbed energy metabolism or inflammatory response to the disease progression.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Marzena Zofia Kastyak
Number of pages:
132
Published on:
2010-08-10
Stock:
Available
Category:
Biochemistry, biophysics
Price:
59.00 €
Keywords:
imaging, Amyotrophic Lateral Sclerosis, Creatine, FTIR Spectroscopy, XRF Fluorescence

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