Bookcover of Histone H1 glycation and rutin metabolites as glycation inhibitors
Booktitle:

Histone H1 glycation and rutin metabolites as glycation inhibitors

Nuclear protein glycation in vivo and novel natural product AGE inhibitors

VDM Verlag Dr. Müller (2010-01-12 )

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ISBN-13:

978-3-639-21224-2

ISBN-10:
363921224X
EAN:
9783639212242
Book language:
English
Blurb/Shorttext:
Protein glycation, induced by hyperglycemia, is implicated in the appearance of diabetic complications and the aging process. Glycation involves the non-enzymatic reaction between sugars and protein amino groups that lead to formation of advanced glycation end products (AGEs). When aminoguanidine, a proven AGE inhibitor, was tested as an anti-diabetic drug in clinical trials showed critical side effects, which suggested a need for improved AGE inhibitors. A protein glycation model included histone H1 and glyoxal or methylglyoxal since it allowed to distinguish AGE inhibitors from antioxidants. This book describes the findings of Dr Cervantes and graduate student, Srinath Pashikanti, of novel natural product AGE inhibitors and the in vivo modification of nuclear proteins, histone H1, with AGE adducts. Rutin metabolic derivatives were tested as AGEs inhibitors since rutin, a flavonoid consumed in fruits and vegetables, is metabolized in the gut. These results suggest effective AGE inhibitors that might be recommended as supplements in diabetes complication prevention. In addition, the occurrence of in vivo nuclear protein glycation is described using histone H1.
Publishing house:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de
By (author) :
Daniel Cervantes-Laurean, Srinath Pashikanti
Number of pages:
52
Published on:
2010-01-12
Stock:
Available
Category:
Biochemistry, biophysics
Price:
49.00 €
Keywords:
Protein chemistry, Glycation, AGE inhibitors, Histone H1, Rutin metabolites, Diabetes complications, Diabetes complications

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