Guardian of Genome Integrity: Cohesin and DNA Damage
Repair
Characterization of the Cohesin Complex during DNA
Double-strand Break Response
978-3-639-00491-5
3639004914
272
2011-09-02
79.00 €
eng
https://images.our-assets.com/cover/230x230/9783639004915.jpg
https://images.our-assets.com/fullcover/230x230/9783639004915.jpg
https://images.our-assets.com/cover/2000x/9783639004915.jpg
https://images.our-assets.com/fullcover/2000x/9783639004915.jpg
Chromosome structure is shaped by the protein
complexes that contain members of the Structural
Maintenance of Chromosome (SMC) family. One of these
protein complexes called cohesin tethers replicated
chromosomes to mediate sister chromatid
cohesion.Sister chromatid cohesion was thought to
play only an indirect role in DNA damage repair. In
this book, we report our detailed analysis of cohesin
in response to a particular type of DNA damage called
DNA double-strand breaks (DSBs).There are three major
conclusions from this work. First,DSBs induce de novo
recruitment of cohesins to the broken chromosomes.
Second,DSBs induce activation of sister chromatid
cohesion by a replication-independent mechanism.
Finally, the DSB-induced cohesin is necessary for the
efficient repair of DNA breaks. Altogether, our
results implicate the direct involvement of cohesin
complex in the maintenance of genomic integrity upon
DNA breaks and suggest that perturbations of
DSB-specific cohesin pathway could play a role in
tumorigenesis.
https://morebooks.de/books/gb/published_by/vdm-verlag-dr-mueller/3/products
Biology
https://morebooks.de/store/gb/book/guardian-of-genome-integrity:-cohesin-and-dna-damagerepair/isbn/978-3-639-00491-5