Bookcover of Evaluation of New Lupane-Type Triterpene 'Diospyrosonate'
Booktitle:

Evaluation of New Lupane-Type Triterpene 'Diospyrosonate'

as Anti-Inflammatory Principle from Diospyros malabarica Bark Extract

LAP LAMBERT Academic Publishing (2011-01-26 )

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ISBN-13:

978-3-8443-0104-5

ISBN-10:
3844301046
EAN:
9783844301045
Book language:
English
Blurb/Shorttext:
A novel lupane-type triterpene 'Diospyrosonate' (P1) has been isolated from anti-inflammatory activity guided fractionation of petroleum ether extract precipitate of Diospyros malabarica stem bark with a gradient of ethyl acetate in petroleum ether. Further P1 was screened for anti- inflammatory activity on carrageenan and dextran induced inflammation model in rats at the dose level of 50 mg/kg body weight. Treatment of inflammed rats with P1 has showed significant reduction in inflammation caused by carrageenan (P<0.05) and dextran (P<0.01). Hence P1 can be considered as the principle component responsible for the anti-inflammatory activity for Diospyros malabarica bark.The characterization of P1 was done by spectral studies like IR, 1H-NMR, 13C-NMR &amp; mass spectroscopy. On the basis of spectral studies the structure of P1 has been elucidated as Betulin esterified at C-29 with a C-14 acid. This is a novel triterpenoid isolated from the bark of D. malabarica for the first time and given a trival name Diospyrosonate.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
VICHITRA KAUSHIK, Versha Parcha, Ratan Lal Khosa
Number of pages:
84
Published on:
2011-01-26
Stock:
Available
Category:
Pharmacy
Price:
49.00 €
Keywords:
"Lupane, Triterpenoid, Anti-Inflammatory, Phytopharmacology.", Triterpenoids, anti-inflammatory, "Phytopharmacology"

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