Bookcover of Development of Compression Coated Colon Targeted 5-Fluorouracil Tablet
Booktitle:

Development of Compression Coated Colon Targeted 5-Fluorouracil Tablet

Development and Characterization of Compression Coated Colon Targeted Tablet of 5-Fluorouracil

LAP LAMBERT Academic Publishing (2012-08-20 )

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ISBN-13:

978-3-659-22194-1

ISBN-10:
3659221945
EAN:
9783659221941
Book language:
English
Blurb/Shorttext:
The purpose of this study was to develop and evaluate a drug delivery system in vitro based on a compression coated tablet containing 5-fluorouracil (5-FU) in core and pectin Hydroxypropyl Methylcellulose (HPMC) mixture in coat layer. The main reason for selecting pectin was its biodegradation in colon by colonic flora. On other hand, high molecular weight HPMC increases mechanical strength of tablet coat around a drug core during its transportation in gastro-intestinal tract. Multiple regression analysis with two way ANOVA revealed that both factors had statistically significant influence for the response studied (P<0.05). Results of Tukey test showed the relative contribution of each level of different factors for the response studied.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Mukesh Patel, Kanu Patel, Natvarlal Patel
Number of pages:
112
Published on:
2012-08-20
Stock:
Available
Category:
Pharmacy
Price:
49.00 €
Keywords:
Factorial Design, Pectin, Hydroxypropyl methylcellulose, 5-Fluorouracil

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