Bookcover of 7-Methoxy-2-Phenyl-1-Benzofuran-5-Carbaldehyde
Booktitle:

7-Methoxy-2-Phenyl-1-Benzofuran-5-Carbaldehyde

Computational Study, Synthesis, Characterisation, MTT And MB Assay

LAP LAMBERT Academic Publishing (2014-03-04 )

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ISBN-13:

978-3-8484-4592-9

ISBN-10:
3848445921
EAN:
9783848445929
Book language:
English
Blurb/Shorttext:
Vanillin undergoes sequence of reaction forming phosphonium salt through dimethyaminomethyl derivative (Mannich reaction). The synthesis of phosphonium salt can be achieved by sequence of three steps which was condense with series of aliphatic/aromatic acid chlorides by refluxing in toluene in presence of triethylamine (Wittig reaction) as key step resulting 7-methoxy-2-phenyl-l-benzofuran-5-carboxaldehyde. The crude product was purified by using column chromatography and characterized by FTIR, NMR and Mass spectroscopy. Computational study of (4) such as Binding energy, density of state, HOMO, LUMO, charge density and reactivity is done by using density functional theory. Based on the results of MTT assay and MB assay, the test compound 04 is shows toxicity against cancerous lung and breast cancer cell lines.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Bapu Thorat, Ravindra Jagtap
Number of pages:
60
Published on:
2014-03-04
Stock:
Available
Category:
Chemistry
Price:
39.90 €
Keywords:
Vanillin, Benzofuran, Computational study, MTT and MB assay, Cytotoxicity

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