Bookcover of 6-APA production by free and agar immobilized bacteria
Booktitle:

6-APA production by free and agar immobilized bacteria

Concepts in microbial bio-conversion of penicillins

LAP LAMBERT Academic Publishing (2012-07-14 )

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ISBN-13:

978-3-659-16045-5

ISBN-10:
3659160458
EAN:
9783659160455
Book language:
English
Blurb/Shorttext:
β- Lactam antibiotics, in particular penicillins and cephalosporins have the annual sales of ~ 65% of the total antibiotics market. Therefore the annual expenditure of penicillin G acylase (PGA) is estimated to be in the range of 10-30 million tons. PGA immobilization preparations (both enzyme and cells) to successfully produce 10,000 tons of total 6-aminopenicillanic acid (6-APA) provide a novel direction to the antibiotics industries promoting a safer and cleaner environment. In the present study, different bacterial samples were isolated from soil of different places of Dibrugarh and screened for biotransformation ability to produce 6-APA. Among ten of them, three gram positive bacterial samples designated as AKDD-2, AKDD-4 and AKDD-6 showed the production of 6-APA from penicillin G. Assessment of 6-APA production after incubation in penicillin G (2mg/ml) by three different samples separately in free and agar immobilization state was done by HPLC analysis. Reusability of immobilized cell was found successful up to 14 days. The work focuses comparison of catalytic properties to produce 6-APA of some industrially valuable soil microorganisms entrapped in agar with the free form.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
https://www.lap-publishing.com/
By (author) :
Sanjoy Das
Edited by:
(Late) Ashoke Kumar Dolui
Number of pages:
136
Published on:
2012-07-14
Stock:
Available
Category:
Pharmacy
Price:
59.00 €
Keywords:
6-aminopenicillanic acid, Bio-conversion, HPLC assessment, Penicillin G, Penicillin G acylase

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