Couverture de THE LINK BETWEEN THYROID HORMONE AND PYRUVATE DEHYDROGENASE KINASE 4
Titre du livre:

THE LINK BETWEEN THYROID HORMONE AND PYRUVATE DEHYDROGENASE KINASE 4

ROLE OF TRANSCRITPTION FACTORS AND COACTIVATORS

VDM Verlag Dr. Müller (12-06-2011 )

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ISBN-13:

978-3-639-36294-7

ISBN-10:
3639362942
EAN:
9783639362947
Langue du livre:
Anglais
texte du rabat:
Pyruvate dehydrogenase kinase 4 (PDK4) regulates pyruvate oxidation through the phosphorylation and inhibition of the pyruvate dehydrogenase complex (PDC). The PDC catalyzes the conversion of pyruvate to acetyl-CoA and it is an important control point in glucose and pyruvate metabolism. Previous studies have showed that PDK4 gene expression is induced by thyroid hormone (T3), however, these studies did not investigate the mechanisms by which T3 regulated PDK4 gene expression. In this book, I have examined the role of the thyroid hormone receptor (TR), transcriptional coactivators especially the peroxisome proliferator activated receptor gamma coactivator-1 (PGC-1α) and and other transcription factors that act as accessory factors in T3 actions. In addition, the book provides a broad insight of the hepatic transcription factors network that work coordinately to facilitate the action of the T3 hormone in the liver. This work may open a door to further investigate therapeutic targets in this network to modulate metabolic disease processes that are affected by the T3 hormone.
Maison d'édition:
VDM Verlag Dr. Müller
Site Web:
http://www.vdm-verlag.de
de (auteur) :
Ramy Raafat Attia
Numéro de pages:
116
Publié le:
12-06-2011
Stock:
Disponible
Catégorie:
Pharmacie
Prix:
329.28 R$
Mots-clés:
Biomedical Science, pharmacology, Thyroid Hormone, PDK4, Transcription factors, coactivator

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