Couverture de Pyrazoles As Potent Antimicrobial Agents
Titre du livre:

Pyrazoles As Potent Antimicrobial Agents

Synthesis, Analysis and Antimicrobial evaluation

LAP LAMBERT Academic Publishing (30-10-2012 )

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ISBN-13:

978-3-659-28536-3

ISBN-10:
3659285366
EAN:
9783659285363
Langue du livre:
Anglais
texte du rabat:
Pyrazole, one of the most important classes of heterocycles, has been the topic of research for thousands of researchers all over the world because of its wide spectrum activities like anti-inflammatory, antipyretic, analgesic, antimicrobial, antihypertensive, antiglaucoma, antioxidant, antidepressent, antiarthritic, neuroprotective, antidiabetic, anticancer, antitubercular, antiviral, and antialzheimer. Pyrazole is the core structural component present in Celecoxib, Deracoxib, Pyrazofurin, Indisteron, Phenazone, Aminopyrine, Sulfinpyrazone, Allopurinol, Phenylbutazone, Famprofazone & many other agents. In the present research work, Diethyl malonate & Substituted Hydrazines were reacted together to give pyrazolidine-3,5-dione nucleus which was further derivatized at fourth position by reacting with different aromatic aldehydes to give 4-benzylidene-pyrazolidine-3,5-diones, followed by the 4-chloro & 4-nitrooxy-butyl substitutions at nitrogen atom. The synthesized products were characterized by physicochemical and analytical means. Few of the synthesized derivatives showed excellent antibacterial and antifungal activities when compared to the standard Ciprofloxacin and Fluconazole.
Maison d'édition:
LAP LAMBERT Academic Publishing
Site Web:
https://www.lap-publishing.com/
de (auteur) :
Harish Arora, Sandeep Jain
Numéro de pages:
96
Publié le:
30-10-2012
Stock:
Disponible
Catégorie:
Education, Emploi, Carrière
Prix:
49.00 €
Mots-clés:
Synthesis, 1, antibacterial, antimicrobial, antifungal, pyrazole, 2-diazoles

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