DNA Gyrase
Bacteria, Antibacterial, Nalidixic acid, Novobiocin, Type II topoisomerase, DNA supercoil, Plasmodium falciparum
978-620-0-16061-4
6200160619
148
2011-12-27
45.00 €
eng
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Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. DNA gyrase, often referred to simply as gyrase, is an enzyme that relieves strain while double-stranded DNA is being unwound by helicase. This causes negative supercoiling of the DNA. Bacterial DNA gyrase is the target of many antibiotics, including nalidixic acid and novobiocin. DNA gyrase is a type II topoisomerase (EC 5.99.1.3) that introduces negative supercoils (or relaxes positive supercoils) into DNA by looping the template so as to form a crossing, then cutting one of the double helices and passing the other through it before releasing the break, changing the linking number by two in each enzymatic step. This process occurs in prokaryotes (in particular, in bacteria), whose single circular DNA is cut by DNA gyrase and the two ends are then twisted around each other to form supercoils.
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