Synthesis and Evaluation of 4-Thiazolidinone Derivatives of Naproxen的封面
书籍主题:

Synthesis and Evaluation of 4-Thiazolidinone Derivatives of Naproxen

Design, Synthesis and Acute Anti-Inflammatory Evaluation of New NSAIDs A Having 4-Thiazolidinone Pharmacophore

Scholars' Press (2018-12-20 )

Books loader

Omni badge 有获得代金券的资格
ISBN-13:

978-613-8-50839-7

ISBN-10:
6138508394
EAN:
9786138508397
书籍语言:
英文
作品简介:
NSAIDs represent one of the most widely used drugs, and are used primarily for the treatment of rheumatoid arthritis. the use of NSAIDs is limited by their ability to induce the formation of erosions and ulcers in GIT. The inhibition of COX-2 produced the therapeutic anti-inflammatory action of NSAIDs, while the undesired side effects arise from inhibition of COX-1 activity. Thus, COX-2 selective inhibitors would have reduced side effects. Inhibition of COX-2 is due to the additional space in the COX-2 hydrophobic channel, as well as to the presence of a side pocket in the channel therefore, a group of (4-thiazolidinone) pharmacophore incorporated to the naproxen; to increase its size were designed, synthesized and evaluated as potential anti-inflammatory agents with expected inhibitory selectivity toward COX-2 enzyme. Purity and characterization of the synthesized compounds were confirmed by determination of physical properties (melting points & Rf values), (FT-IR), (1H-NMR) spectroscopy and elemental microanalysis. Compounds (Va-e) exhibited higher anti-inflammatory effect than naproxen (50mg/kg, i.p.) at 180-240 min., while compound Vf exhibited lower anti-inflammatory effects.
出版社 :
Scholars' Press
网址:
http://www.scholars-press.com
由(作者):
Farah AbdulHaleem, Monther F. Mahdi, Ayad Mohamed Rasheed
页码 :
136
发表日期:
2018-12-20
现货:
备有现货
类别:
药学
价格:
67.90 €
关键词:
Naproxen, 4-Thiazolidinone, Anti-inflammatory

Books loader

时事通讯

Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Paypal CryptoWallet 银行转帐

LOGIN
  0产品在购物车内
编辑购物车
Loading frontend
LOADING