Formulation and Optimization of Solid Dispersions by BoxBehnken Design的封面
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Formulation and Optimization of Solid Dispersions by BoxBehnken Design

Box-behnken Design - An effective tool in Solid Dispersion

LAP LAMBERT Academic Publishing (2012-06-17 )

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ISBN-13:

978-3-659-15959-6

ISBN-10:
365915959X
EAN:
9783659159596
书籍语言:
英文
作品简介:
The objective of this study was to prepare and evaluate solid dispersion of poorly water soluble drug Telmisartan, a candidate mainly from the class II category of BCS classification, to increase solubility and for enhancement of bioavailability. The solid dispersions were prepared by physical mixture method using PEG 6000, Eudrajit L 100 and PVP K 30 as a carrier. A Box Behnken design has been applied to study the effect of independent variables i.e. PEG 6000, Eudrajit L 100 and PVP K 30 on dependent variables i.e. % Cumulative Drug Release and time required for cumulative drug release . Response surface plots and counter plots were drawn and optimum formulations were selected based on feasibility search method. Validation of optimized study performed using three confirmatory runs indicated very high degree of prognostic ability of response surface methodology, with mean percentage error as +0.02. Optimized solid dispersion formulations were prepared and its effect on % Cumulative Drug Release and time was evaluated. Optimized solid dispersions were evaluated for % CDR and Time for CDR, FTIR, DSC, SEM and in vitro drug release study.
出版社 :
LAP LAMBERT Academic Publishing
网址:
https://www.lap-publishing.com/
由(作者):
Niranjan Chivate, Anuradha Chivate
页码 :
196
发表日期:
2012-06-17
现货:
备有现货
类别:
药学
价格:
68.00 €
关键词:
solid dispersion, BCS classification, Telmisartan, Box Behnken design, PEG 6000, EUD L 100, PVP K 30, Physical Mixture method.

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