Fomulation And Evaluation Of Nsaid's By Liquisolid Compact Technique的封面
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Fomulation And Evaluation Of Nsaid's By Liquisolid Compact Technique

A Liquisolid Compact A Reliable Tool For Solubility Enhancement

LAP LAMBERT Academic Publishing (2012-11-14 )

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ISBN-13:

978-3-659-29557-7

ISBN-10:
3659295574
EAN:
9783659295577
书籍语言:
英文
作品简介:
Liquisolid compacts were used to formulate water insoluble drugs in non-volatile solvents and converting into acceptably flowing and compressible powders. The main objective of present investigation was to enhance the dissolution rate of water insoluble drugs Ibuprofen and Naproxen by using liquisolid technique. Several liquisolid tablets were prepared by using different carrier materials.PEG 400 was used as non- volatile water miscible liquid vehicle. The liquid loading factors for such liquid vehicle was calculated to obtain the optimum amounts of carrier and coating materials necessary to produce acceptable flowing and compactable powder admixtures viable to produce compacts. The formulated liquisolid tablets were evaluated for post compression parameters such as weight variation, hardness, drug content, content uniformity, percentage friability and disintegration time. The in-vitro release characteristics of the drug from marketed tablets and liquisolid technique were studied. XRD,DSCand FTIR were performed. The results showed that liquisolid formulations of Ibuprofen and Naproxen exhibited higher percentage of drug release than marketed formulation.
出版社 :
LAP LAMBERT Academic Publishing
网址:
https://www.lap-publishing.com/
由(作者):
Mohan Dhere, Niranjan Chivate
页码 :
184
发表日期:
2012-11-14
现货:
备有现货
类别:
药学
价格:
68.00 €
关键词:
Dissolution, Ibuprofen, Naproxen, Liquisolid compacts, Content uniformity.

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