Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum的封面
书籍主题:

Enhancement of Solubility and Dissolution Rate Using Modified Guar Gum

Enhancement of Bioavailability by Using Natural Polymer

LAP LAMBERT Academic Publishing (2013-02-01 )

Books loader

Omni badge 有获得代金券的资格
ISBN-13:

978-3-659-33753-6

ISBN-10:
3659337536
EAN:
9783659337536
书籍语言:
英文
作品简介:
Present study examines the effect of Guar gum (GG) and Modified guar gum (MGG) on the oral bioavailability of a poorly water-soluble drug, Ibuprofen (IBU). Modified guar gum (MGG) was prepared using heat treatment (125-130oC for 2 to 3 hours) method. It was characterized for viscosity, swelling index and water retention capacity. The physical and co-grinding mixtures of IBU with GG and MGG were prepared in 1:9 drug to gum ratio. The physical and co-grinding mixtures were characterized by DSC, FT-IR. The studies confirmed that there was no interaction between drug and carrier. Prepared mixtures were evaluated for solubility study and in vitro dissolution studies. The rank order of solubility was IBU<grounded IBU<Physical mixture< Co-grinding mixture <Co-grinding mixture of IBU and MGG. The bioavailability study of IBU:GG and IBU:MGG mixture were done using male Sprague-Dawley rats. Drug serum concentration was estimated using HPLC method. Cmax value of ibuprofen found in case of IBU:MGG was higher as compared to pure IBU:GG mixtures. About 49 % improvement in oral bioavailability of ibuprofen was resulted with IBU:MGG mixture.
出版社 :
LAP LAMBERT Academic Publishing
网址:
https://www.lap-publishing.com/
由(作者):
Vipul Jambukiya, Ramesh Parmar, N. R. Sheth
页码 :
92
发表日期:
2013-02-01
现货:
备有现货
类别:
药学
价格:
49.00 €
关键词:
Ibuprofen, Poorly soluble drug, Guar gum, Modified guar gum, Dissolution rate enhancement, Co-grinding, Oral Bioavailability studies, Solubility

Books loader

时事通讯

Adyen::diners Adyen::jcb Adyen::discover Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Adyen::paypal Paypal CryptoWallet 银行转帐

LOGIN
  0产品在购物车内
编辑购物车
Loading frontend
LOADING