Benzimidazole-2-carboxylic acids的封面
书籍主题:

Benzimidazole-2-carboxylic acids

Chemistry, Pharmacology and QSAR

LAP LAMBERT Academic Publishing (2010-10-31 )

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ISBN-13:

978-3-8433-7236-7

ISBN-10:
3843372365
EAN:
9783843372367
书籍语言:
英文
作品简介:
Rheumatoid arthritis is progressive, autoimmune inflammatory chronic disorder which do not have curative treatment yet. Aryl and hetero-aryl acids has maximum share of anti-inflammatory drugs in the therapeutics today as non steroidal anti-inflammatory drugs (NSAIDs). Benzimidazole moiety with heteroaryl and psudoacedic nature is promising moiety for development of NSAIDs. In the present project, synthesis, pharmacological evaluation, probable mechanism of action and quantitative structure-activity relationship (QSAR) of benzmidazole-2-carboxylic acids are reported. The excellent efficacy and safety was observed for benzimidaxole-2-carboxylic acid derivatives in laboratory animal models of inflammation and rheumatoid arthritis without side-effect of gastrointestinal disturbances. The reliving effects against pain and fever in experimental animal models suggested promise as potential NSAID.
出版社 :
LAP LAMBERT Academic Publishing
网址:
https://www.lap-publishing.com/
由(作者):
Prasad Thakurdesai, S.G. Wadodkar, C.T. Chopde
页码 :
124
发表日期:
2010-10-31
现货:
备有现货
类别:
药学
价格:
59.00 €
关键词:
pharmacology, Rhumatoid Arthritis, Benzimidazole, Anti-Inflammatory, Analgesic, Antipyretic, Synthesis, QSAR, In vivo, In vitro, Mechanism of action, Pharmacology, anti-inflammatory, analgesics, antipyretic, In Vitro

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