Acridine: A Potential Source Of Anticancer Agents的封面
书籍主题:

Acridine: A Potential Source Of Anticancer Agents

Design, Synthesis and Biological Evaluation

LAP LAMBERT Academic Publishing (2012-12-01 )

Books loader

Omni badge 有获得代金券的资格
ISBN-13:

978-3-659-30576-4

ISBN-10:
3659305766
EAN:
9783659305764
书籍语言:
英文
作品简介:
Cancer is a major health problem in the developed and developing Countries.Inspired by the wide range of useful activities possessed by the acridine derivatives and in continuation of our efforts in search of potential anticancer agents, we have synthesized 9-anilinoacridine derivative and 9-anilino-2-methoxy acridine derivatives. The newly synthesized compounds evaluated for anticancer activities against two cancer cell lines i.e. human small cell lung cancer (A-549) cell line and human endothelial cervical cancer (HeLa) cell line in vitro by MTT assay. The most potent compound among the tested compound from above described was evaluated for in vitro short term anticancer study by Dalton’s Lymphoma Ascites (DLA). An effect of acridine derivatives on DNA synthesis raised the hypothesis that acridine moieties secondary effect on biochemical pathways, including protein and lipid metabolism exists, which suggest acridine derivatives could be considered multi targets drugs.Structural modification may lead to synthesize more acridine derivatives. The present study opens new vista for DNA intercalating anticancer compounds and their further in vivo investigation.
出版社 :
LAP LAMBERT Academic Publishing
网址:
https://www.lap-publishing.com/
由(作者):
Puneet Kumar, Anuradha Soni
页码 :
96
发表日期:
2012-12-01
现货:
备有现货
类别:
药学
价格:
49.00 €
关键词:
Cervical cancer, lung cancer, Topoisomerase, 9-Aminoacridine, Dalton Lymphoma Ascites, Multidrug Resistance.

Books loader

时事通讯

Adyen::amex Adyen::mc Adyen::visa Adyen::cup Adyen::unionpay Paypal CryptoWallet 银行转帐

LOGIN
  0产品在购物车内
编辑购物车
Loading frontend
LOADING